Diabetes is a dangerous metabolic condition that is treated with a variety of medicinal herbs in conventional medicine. Plant extracts are widely used in Nigeria as important sources of antidiabetic agents, despite the use of synthetic drugs by the vast majority of the populace. Rhuslongipesis well-known for its conventional therapeutic usage. With the use of insilico approach, the current study aims at investigating the molecular docking and ADME/drug screening of bioactive components found in the Rhuslongipes leaf ethanol extract. Using Pyrx software, molecules were molecularly docked to two target proteins: aldose reductase and α-glucosidase. SwissADME, an online application, was used to calculate the physicochemical, ADMET, and drug similarity characteristics. Because of the strong binding affinities between the chemicals octadecanamide, 2-[3-(cyclohexylamino) propyl]-guanidine, elaidic acid, and caffeic acid and at least one of two target proteins, the results validated the plant's antidiabetic properties. Eight compounds (four of each): estriol, cholest-2-Eno[2,3-B], (+)-catechin, Apigenin; octadecanamide, 2-[3(cyclohexylamino)propyl] -guanidine, elaidic acid, and caffeic acid; and estriol, cholest-2-eno [2, 3B], gave the best binding score for target proteins, for which relatively optimal drug-like and pharmaceutical chemistry properties were identified. The plant's ethanol extract was shown to have antidiabetic properties in our most recent investigation, and we also found a number of potentially useful chemicals. Consequently, the current study came to the conclusion that these compounds might have had a role in the plant's reported antidiabetic qualities and might further be studied as prospective medications.